PROJECT OF RFBR No. 05-08-33354-a
"Development of base principles of organization of hardware, software
and methodical providing of non-invasive laser multifunctional
diagnostic systems for medicine"
(October 2005 - December 2006)
Abstract
This project has been directed in development and creation of scientific and engineering foundations of organization, functioning, projecting and simulation of a new class of optical and medical diagnostic equipment - multifunctional laser noninvasive diagnostic systems (MLNDS). In the project a previous scientific and practical experience of MONIKI in the field of laser noninvasive clinical diagnostics was summarized. With the use of that the scientific-based requirements to functional units and block’s composition of the most promising diagnostic equipment in this brunch – the MLNDS - were developed and formulated. To be aimed at creation of specific engineer theory of development and constructing of MLNDS the structure-functional model of generalized MLNDS was designed. On the basis of a complex bio-technical approach to the problem the aim function of generalized MLNDS was determined and formulated. The basic principles of block-modules composition of MLNDS’ hardware were investigated and developed. Problems of metrological providing for MLNDS were considered. A new important item of “diagnostic volume” was introduced as one of the key items in a metrology of noninvasive laser examination in a medicine. A special set of medical and technical requirements to MLNDS as well as the general approach to the MLNDS’ design and creation process were developed and suggested. In a part of foundation and development of calculation algorithms for data processing in MLNDS the different known and new physical and mathematical algorithms, basing on the radiative transport and scattering theory, were tested. It was shown, that in the classical transport theory there are a number of calculation problems in which standard solution with separated transport coefficients of main equations leads to some errors in a boundary fluxes magnitudes. The general modification of the classical Kubelka-Munk approach was suggested to avoid this effect in the theory. This modification, in contradiction to the well-known literature data, allowed us to yield exact analytical solutions of any direct one-dimensional tasks for any kind of scattering media in application to the medical laser noninvasive diagnostic procedures, that became a foundation to choose a modified Kubelka-Munk model as a base calculation model in the system software of MLNDS.